What is the difference between RadMail and a send-only ESP?
A send-only email service provider (ESP) sends outbound mail and reports opens and clicks, but it never sees the replies, so it cannot tell you which sends actually earned a reply. RadMail ingests inbound mail and sends outbound, so it can do reply-correlation — connecting a send to the response it produced — which a send-only ESP is structurally unable to do.
If you need to know what got a reply, not just an open, a send-only ESP can't answer that — RadMail can.